Collecting/Banking Bone Marrow&Blood for Pts w/Relapsed ALL & NHL

A Children’s Oncology group protocol for collecting and banking relapsed acute lymphoblastic Leukemia research Specimens

November 22, 2017

  • Clinical Trial Information

    Trial Contact: Boettger, Sadie; El-Shami, Jessica; Francois, Laetitia Claire; Spinelli, Jennifer

  • IRB No: AALL05B1

    Protocol Abbrev: AALL05B1

    Principal Investigator: Vincent F. Giusti, MD

    Sub Investigators: AguilarBonilla, Ana MD; Eslin, Don MD; Martin, Rebecca, ARNP; Pope, Michele ARNP; Smith, Amy MD; Story, Allison ARNP; Sullivan Darden, Kelly ARNP; Sutphin, Robert MD; Wieber, Laura ARNP; Levy, Alejandro MD

    Age Group: Pediatric

    Secondary Protocol No: AALL05B1

    Treatment: Other: biologic sample preservation procedure

    Applicable Disease Sites: Leukemia

    Therapies Involved: Procedural

    ClinicalTrials.gov ID: NCT00897325

  • Objective

    Collecting and storing samples of bone marrow and blood from patients with cancer may help doctors learn more about cancer and help predict recurrence.

  • Key Eligibility

    Eligibility

    Ages Eligible for Study: up to 30 Years
    Genders Eligible for Study: Both
    Accepts Healthy Volunteers: No
    Sampling Method: Non-Probability Sample

    Study Population

    Patients newly diagnosed with acute lymphoblastic leukemia (ALL) or prior history of non-Hodgkin lymphoma.

    Inclusion Criteria:
    •  Diagnosis of acute lymphoblastic leukemia (ALL) or prior history of non-Hodgkin lymphoma
    •  In first or subsequent marrow relapse with ≥ 25% blasts in bone marrow and/or peripheral blood
    •  Bone marrow and/or peripheral blood samples (≥ 5 mL) required at the time of diagnosis of relapse
    •  No concurrent systemic antileukemic treatment administered for current relapse
    ◦Intrathecal chemotherapy allowed
    ◦On-therapy relapse allowed