Small Intestinal Permeability and Obesity in Children
Clinical Trial Information
Trial Contact: Kern, Katelyn D; Preciado, Jeannine
IRB No: 18.115.09
Protocol Abbrev: S/I Perm & Obesity
Principal Investigator: Shaista Syeda Safder, MD
Age Group: Pediatric
To investigate whether intestinal permeability, correlates with the obesity and NAFLD as measured by clinical symptoms scores and routine medical tests.
• Determine whether the standard therapeutic and dietary interventions to treat obesity and NAFLD will have changes in intestinal permeability markers. Follow intestinal permeability trend overtime to compare if there is a change in permeability as markers for obesity improve with treatment in our Healthy Lifestyles Clinic (i.e. comparing permeability of those who lose weight or maintain weight vs those who gain weight).
• Assess correlation of lactulose/mannitol testing with serological markers of permeability (serum I-FABP, serum bile acids, and serum endotoxin), bacterial overgrowth, and serological/clinical markers for NAFLD.
• Patients aged between 5-19 years old, BMI>95%tile, enrolled in our Healthy Lifestyles Program
• Patients who are fasting at least 4 hours prior to their initial visit