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Small Intestinal Permeability and Obesity in Children

Small Intestinal Permeability and Obesity in Children

  • Clinical Trial Information

    Trial Contact: Kern, Katelyn D; Preciado, Jeannine

    Trial Phone: 321.841.9560 ; 321.841.3938

  • IRB No: 18.115.09

    Protocol Abbrev: S/I Perm & Obesity

    Principal Investigator: Shaista Syeda Safder, MD

    Age Group: Pediatric

  • Objective

    To investigate whether intestinal permeability, correlates with the obesity and NAFLD as measured by clinical symptoms scores and routine medical tests.
    •   Determine whether the standard therapeutic and dietary interventions to treat obesity and NAFLD will have changes in intestinal permeability markers. Follow intestinal permeability trend overtime to compare if there is a change in permeability as markers for obesity improve with treatment in our Healthy Lifestyles Clinic (i.e. comparing permeability of those who lose weight or maintain weight vs those who gain weight).
    •   Assess correlation of lactulose/mannitol testing with serological markers of permeability (serum I-FABP, serum bile acids, and serum endotoxin), bacterial overgrowth, and serological/clinical markers for NAFLD.

  • Key Eligibility

    •   Patients aged between 5-19 years old, BMI>95%tile, enrolled in our Healthy Lifestyles Program
    •   Patients who are fasting at least 4 hours prior to their initial visit